Mary M Machulda Selected Research

Apraxias (Dyspraxia)

9/2020	Ioflupane 123I (DAT scan) SPECT identifies dopamine receptor dysfunction early in the disease course in progressive apraxia of speech.
1/2020	Longitudinal flortaucipir ([18F]AV-1451) PET imaging in primary progressive apraxia of speech.
1/2018	Disrupted functional connectivity in primary progressive apraxia of speech.
1/2016	Clinical and MRI models predicting amyloid deposition in progressive aphasia and apraxia of speech.
11/2014	APOE ε4 influences β-amyloid deposition in primary progressive aphasia and speech apraxia.

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Mary M Machulda Research Topics

Disease

53	Alzheimer Disease (Alzheimer's Disease) 06/2022 - 01/2014
38	Cognitive Dysfunction 01/2022 - 07/2013
28	Dementia (Dementias) 01/2022 - 11/2014
13	Atrophy 06/2022 - 12/2014
8	Tauopathies 01/2022 - 09/2015
8	Primary Progressive Aphasia 12/2019 - 12/2013
6	Aphasia (Dysphasia) 01/2020 - 12/2013
5	Amyloidosis 01/2021 - 12/2015
5	Frontotemporal Dementia (Semantic Dementia) 01/2021 - 03/2012
5	Apraxias (Dyspraxia) 09/2020 - 11/2014
4	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome) 01/2022 - 01/2018
4	Vascular Diseases (Vascular Disease) 01/2022 - 01/2015
3	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 01/2021 - 01/2020
3	Corticobasal Degeneration 11/2020 - 01/2018
3	Cerebral Cortical Thinning 12/2019 - 01/2019
3	Chronic Disease (Chronic Diseases) 01/2019 - 05/2015
3	Hypertension (High Blood Pressure) 01/2018 - 05/2015
3	Obesity 01/2018 - 01/2015
2	Disease Progression 01/2021 - 01/2020
2	Cerebrovascular Disorders (Cerebrovascular Occlusion) 01/2021 - 12/2020
2	Lewy Body Disease (Lewy Body Dementia) 01/2021 - 01/2018
2	Multiple Sclerosis 01/2020 - 01/2018
2	Amyloid Plaque 07/2019 - 01/2019
2	Dyslipidemias (Dyslipidemia) 01/2019 - 01/2017
2	Hyperlipidemias (Hyperlipidemia) 01/2018 - 11/2017
2	Hippocampal Sclerosis 01/2018 - 01/2017
2	Olfaction Disorders (Cacosmia) 06/2017 - 01/2016
2	Language Disorders (Language Disorder) 11/2014 - 03/2014
1	Chronic Renal Insufficiency 01/2022
1	Genetic Risk Score 01/2022
1	Neoplasms (Cancer) 11/2021
1	Anomia (Dysnomia) 01/2021
1	Pathologic Processes 01/2021
1	Pick Disease of the Brain (Pick's Disease) 11/2020
1	Agammaglobulinemia (Hypogammaglobulinemia) 08/2020
1	Cataplexy 08/2020
1	Hearing Loss (Hearing Impairment) 08/2020
1	Narcolepsy 08/2020
1	Optic Atrophy 08/2020
1	Seizures (Absence Seizure) 08/2020
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2020
1	Proteostasis Deficiencies 10/2019
1	Disorders of Excessive Somnolence (Hypersomnia) 01/2018
1	Type 2 Diabetes Mellitus (MODY) 01/2018
1	Anosmia 06/2017
1	Alcoholism (Alcohol Abuse) 01/2017
1	Parkinson Disease (Parkinson's Disease) 01/2017
1	Stroke (Strokes) 01/2017
1	Normal Pressure Hydrocephalus 01/2017
1	Subdural Hematoma (Subdural Hemorrhage) 01/2017
1	Brain Infarction 03/2015
1	Unconsciousness (Loss of Consciousness) 01/2014
1	Craniocerebral Trauma (Head Injury) 01/2014
1	Frontotemporal Dementia With Motor Neuron Disease 03/2012

Drug/Important Bio-Agent (IBA)

65	Amyloid (Amyloid Fibrils)IBA 04/2022 - 12/2013
38	Biomarkers (Surrogate Marker)IBA 01/2022 - 12/2014
13	2- (4'- (methylamino)phenyl)- 6- hydroxybenzothiazole (Pittsburgh compound B)IBA 01/2020 - 12/2013
12	Apolipoproteins E (ApoE)IBA 06/2022 - 11/2014
9	7- (6- fluoropyridin- 3- yl)- 5H- pyrido(4,3- b)indoleIBA 01/2021 - 01/2017
7	ApolipoproteinsIBA 06/2022 - 11/2014
7	Amyloid beta-PeptidesIBA 01/2021 - 01/2016
6	Biological ProductsIBA 01/2021 - 03/2015
4	Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link 01/2022 - 12/2014
4	Apolipoprotein E4IBA 01/2019 - 12/2015
3	Proteins (Proteins, Gene)FDA Link 01/2021 - 01/2019
2	Glucose (Dextrose)FDA LinkGeneric 01/2021 - 01/2019
2	2- carbomethoxy- 8- (3- fluoropropyl)- 3- (4- iodophenyl)tropaneIBA 09/2020 - 01/2018
2	Protons (Proton)IBA 11/2017 - 07/2013
2	ProgranulinsIBA 01/2015 - 03/2014
1	Carrier Proteins (Binding Protein)IBA 01/2022
1	Protein Isoforms (Isoforms)IBA 01/2022
1	SynucleinsIBA 01/2021
1	DNA-Binding Proteins (DNA Binding Protein)IBA 01/2021
1	ioflupaneIBA 09/2020
1	Dopamine Receptors (Dopamine Receptor)IBA 09/2020
1	Intravenous Immunoglobulins (IVIG)FDA Link 08/2020
1	GadoliniumIBA 08/2020
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 12/2019
1	InterleukinsIBA 12/2019
1	Interleukin-6 (Interleukin 6)IBA 12/2019
1	CytokinesIBA 12/2019
1	Interleukin-10 (Interleukin 10)IBA 12/2019
1	Phosphatidylcholines (Phosphatidylcholine)IBA 01/2019
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2019
1	SolutionsIBA 01/2019
1	Insulin (Novolin)FDA Link 01/2018
1	Metformin (Glucophage)FDA LinkGeneric 01/2018
1	Hypoglycemic Agents (Hypoglycemics)IBA 01/2018
1	Inositol (Myoinositol)IBA 11/2017
1	Glutamic Acid (Glutamate)FDA Link 11/2017
1	Adenosine Diphosphate (ADP)IBA 01/2017
1	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 01/2015
1	CarbonIBA 12/2014
1	N 30IBA 03/2012

Therapy/Procedure

1	Ovariectomy (Oophorectomy) 11/2021
1	Cochlear Implantation 08/2020
1	Activities of Daily Living (ADL) 01/2020
1	Secondary Prevention 09/2017
1	Mediterranean Diet 01/2017
1	Therapeutics 09/2015